Ebumnuche nke ọmụmụ ihe a bụ inye data gbasaraọgwụ ahụhụiguzogide ime mkpebi na mmemme njikwa iguzogide na Togo.
E jiri usoro nnwale WHO in vitro nyochaa ọnọdụ nnabata nke Anopheles gambiae (SL) nye ọgwụ ahụhụ e ji eme ihe n'ahụike ọha. E mere nyocha bioasys maka iguzogide pyrethroid dịka usoro nnwale karama CDC si dị. E jiri usoro synergists piperonyl butoxide, SSS-phosphorothioate, na ethacrine nwalee ọrụ enzyme iwepụ ihe na-egbu egbu. Nchọpụta na genotyping nke ụdị kdr na Anopheles gambiae SL site na iji teknụzụ PCR.
Ndị bi n'ógbè Anopheles gambiae sl gosiri na ha nwere ike ibute pirimiphos-methyl kpamkpam na Lomé, Kowie, Aniye na Kpeletutu. Ọnwụ ha dị pasent 90 na Bayda, nke na-egosi na ha nwere ike iguzogide pirimiphos-methyl. E dekọrọ nguzogide DDT, benzodicarb na propoxur n'ebe niile. E dekọrọ oke nguzogide pyrethroids dị elu, yana oxidases, esterases na glutathione-s-transferases bụ enzymes na-eme ka nsị dị ọcha na-akpata nguzogide, dịka ule synergistic si kwuo. Ụdị ndị bụ isi achọpụtara bụ Anopheles gambiae (ss) na Anopheles cruzi. A chọpụtara ugboro ole kdr L1014F dị elu na obere ugboro ole kdr L1014S alleles n'ebe niile.
Ọmụmụ ihe a na-egosi mkpa ọ dị maka ngwaọrụ ndị ọzọ iji mee ka usoro ọgwụgwọ ịba nke e ji ọgwụ ahụhụ mee ka ọ sie ike (IRS na LLIN).
Ojiji nke ọgwụ ahụhụ bụ akụkụ dị mkpa nke mmemme njikwa vektọ ịba na Afrịka [1]. Agbanyeghị, mpụta nke iguzogide ụdị ọgwụ ahụhụ ndị bụ isi eji agwọ bednet na ịgba ọgwụ mgbochi n'ime ụlọ (IRS) chọrọ ka anyị tụlee ojiji nke ngwaahịa ndị a na njikwa iguzogide vektọ [2]. Akọpụtala mpụta nke iguzogide ọgwụ na mba dị iche iche na West Africa gụnyere Benin, Burkina Faso, Mali [3, 4, 5] na karịsịa Togo [6, 7]. Ọmụmụ ihe ndị na-adịbeghị anya egosila na iji ndị na-eme ihe na njikọta nke ọgwụ ahụhụ na-eme ka ndị na-eme ihe ... Dịka ndụmọdụ nke Òtù Ahụike Ụwa (WHO) si kwuo [10], njikwa iguzogide gụnyere itinye usoro nzọụkwụ atọ gụnyere (1) nyocha nke ọnọdụ nnabata nke ọgwụ ahụhụ nke vektọ, (2) njirimara nke ike iguzogide, na (3) nyocha nke usoro physiological, na-elekwasị anya karịsịa na irè nke synergist piperonyl butoxide (PBO). Na Togo, a na-eme nzọụkwụ mbụ, nyocha nke ọnọdụ nnabata nke ọgwụ ahụhụ nke ọgwụ ahụhụ, kwa afọ 2-3 na ebe nchekwa nke Mmemme Njikwa Ọrịa Malaria nke Mba (NMCP). A mụọbeghị ike iguzogide na irè nke usoro abụọ ikpeazụ (ya bụ, potentiators piperonyl butoxide (PBO), S,S,S-tributyl trisulfate phosphate (DEF), na ethacrynic acid (EA)) nke ọma.
Ebumnuche nke ọmụmụ a bụ ileba anya n'akụkụ atọ ndị a ma nye NMCP data a pụrụ ịtụkwasị obi iji mee mkpebi gbasara njikwa iguzogide na Togo.
E mere nnyocha a site na June ruo Septemba 2021 na ebe ndị nche NMCP ahọpụtara na mpaghara ahụike atọ dị na ndịda Togo (Foto nke 1). Ahọpụtara ebe nlekota NMCP ise maka nlekota dabere na mpaghara ha (ebe dị iche iche dị ọcha) na njirimara gburugburu ebe obibi (ọtụtụ vektọ, ebe ọmụmụ nwa na-adịgide adịgide): Lomé, Bayda, Kowie, Anyere na Kpeletoutou (Tebụl 1).
Nnyocha a na-egosi na ọnụọgụ anwụnta Anopheles gambiae dị na ndịda Togo na-eguzogide ọtụtụ ọgwụ nje dị mkpa maka ahụike ọha na eze, ewezuga pirimiphos-methyl. A hụrụ ọkwa dị elu nke iguzogide pyrethroid n'ebe a na-amụ ihe, ikekwe jikọtara ya na enzymes na-eme ka ihe dị ọcha (oxidases, esterases na glutathione-s-transferases). A chọpụtara mgbanwe kdr L1014F n'ime ụdị nwanne abụọ Anopheles gambiae ss na Anopheles kruzi nwere ugboro allele dị iche iche mana dị elu (>0.50), ebe mgbanwe kdr L1014S mere na ugboro dị ala ma a hụrụ ya naanị na anwụnta Anopheles cruzi. Ndị na-eme ihe nkiri PBO na EA weghachiri mmetụta nke pyrethroids na organochlorines, n'otu n'otu, n'ebe niile, ebe DEF mụbara mmetụta nke carbamates na organophosphates na ebe niile ewezuga Anye. Data ndị a nwere ike inyere Mmemme Njikwa Malaria Mba Togolese aka ịmepụta atụmatụ njikwa vektọ dị irè karị.
Oge ozi: Disemba-23-2024